Embryonic Stem Cell Self-Renewal, Analyzed
نویسندگان
چکیده
منابع مشابه
Embryonic Stem Cell Self-Renewal, Analyzed
Maintaining the pluripotency of mouse ES cells requires both LIF (leukemia inhibitory factor) and unknown factors in serum. The paper from Ying et al. in this issue of Cell shows that BMP (bone morphogenetic protein) can replace serum in this capacity, defining molecular requirements for ES cell self-renewal.
متن کاملMicroRNA Regulation of Embryonic Stem Cell Self-Renewal and Differentiation.
Stem cell differentiation requires a complex coordination of events to transition from a self-renewing to a differentiated cell fate. Stem cells can be pluripotent (capable of giving rise to all embryonic lineages), multipotent (possessing the potential to give rise to multiple lineages) and unipotent (capable of given rise to a single cell lineage). Regardless of their potency all stem cells m...
متن کاملWnt pathway regulation of embryonic stem cell self-renewal.
Embryonic stem cells (ESCs) can generate all of the cell types found in the adult organism. Remarkably, they retain this ability even after many cell divisions in vitro, as long as the culture conditions prevent differentiation of the cells. Wnt signaling and β-catenin have been shown to cause strong effects on ESCs both in terms of stimulating the expansion of stem cells and stimulating differ...
متن کاملAlbumin-Associated Lipids Regulate Human Embryonic Stem Cell Self-Renewal
BACKGROUND Although human embryonic stem cells (hESCs) hold great promise as a source of differentiated cells to treat several human diseases, many obstacles still need to be surmounted before this can become a reality. First among these, a robust chemically-defined system to expand hESCs in culture is still unavailable despite recent advances in the understanding of factors controlling hESC se...
متن کاملAlternative Splicing in Self-Renewal of Embryonic Stem Cells
Much of embryonic stem cell biology has focused on transcriptional expression and regulation of genes that could mediate its unique potential in self-renewal or pluripotency. In alignment with our present understanding on the genetic, protein, and epigenetic factors that may direct cell fate, we present a short overview of the often overlooked contribution of alternative splice variants to regu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2003
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(03)00853-5